The aim of the present study was to formulate fast dissolving tablet of oseltamivir using superdisintegrants with the help of solid dispersion technique to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Solid dispersion of oseltamivir was prepared with PVP K30 in different drug: carrier ratio using solvent evaporation methods. The optimized solid dispersion (drug: PVP K30, 1:0.5 ratio) were further used to prepare fast dissolving tablet by direct compression method using superdisintegrants such as crospovidone and xanthan gum. Infrared spectroscopy, differential scanning calorimetry and x-ray diffraction were performed to identify the physicochemical interaction between drug and optimized formulation. The pre-compression parameter of prepared powder blends all formulation suggested good flowability and compressibility. The prepared tablets were evaluated for thickness, hardness, friability and weight variation, drug content, wetting time, disintegration time and in-vitro dissolution studies. The batch F12- shows highest release of 99.87 % in 25 min.
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